MAN2A1 predicts prognosis and progression through cancer-related pathways in colorectal cancer.

ABSTRACT:

Background

Colorectal cancer (CRC) is a common malignant tumor leading to poor prognosis and high mortality. Mannosidase alpha class 2A member 1 (MAN2A1) turns to oncogene through fusing Fer tyrosine kinase (FER) and associates with multiple cancer occurrence. In order to determine whether MAN2A1 can promote tumorigenesis and metastasis in CRC, we conducted a series of studies.

Methods

We obtained gene expression and clinical data of CRC from The Cancer Genome Atlas (TCGA) databases. RNA raw counts data was merged by Python. Batch processing of univariate Cox regression analysis was performed to preliminary identify the genes associated with prognosis. Differentially expressed genes (DEGs) between lymph node metastasis (LNM) patients and non-LNM patients

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9641108 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature