Development and validation of a novel ubiquitination-related gene prognostic signature based on tumor microenvironment for colon cancer.

ABSTRACT:

Background

Colon cancer (CC) is one of the most common cancers with high morbidity globally. Ubiquitination is involved in the characterization of multiple biological processes, and some ubiquitinated enzymes are associated with the prognosis of CC. However, the prognostic model associated with ubiquitination-related genes (URGs) for CC is unavailable.

Methods

Gene expression data, somatic mutations, transcriptome profiles, microsatellite instability status (MSI) status, and clinical information for CC were obtained from The Cancer Genome Atlas (TCGA) dataset. Seven URGs were used for establishing a prognostic prediction model, which was constructed and validated in GSE17538. Besides, genomic variance analysis (GSVA) was used to explore further the differences in biological

SUBMITTER: Huang B 

PROVIDER: S-EPMC9641125 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature