Associations between maternal obesity and offspring gut microbiome in the first year of life.

ABSTRACT:

Background

Maternal obesity is an important determinant of offspring obesity risk, which may be mediated via changes in the infant microbiome.

Objectives

We examined infant faecal microbiome, short-chain fatty acids (SCFA), and maternal human milk oligosaccharides (HMO) in mothers with overweight/obese body mass index (BMI) (OW) compared with normal weight (NW) (Clinicaltrials.gov NCT01131117).

Methods

Infant stool samples at 1, 6, and 12 months were analysed by 16S rRNA sequencing. Maternal (BODPOD) and infant (quantitative nuclear magnetic resonance [QMR]) adiposity were measured. HMOs at 2 months postpartum and faecal SCFAs at 1 month were also assessed. Statistical analyses included multivariable and mixed linear models for assessment of microbiome diversity, comp

SUBMITTER: Gilley SP 

PROVIDER: S-EPMC9641193 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature