Age-differential sexual dimorphism in CHD8-S62X-mutant mouse behaviors.

ABSTRACT: Autism spectrum disorders (ASD) are ~4-times more common in males than females, and CHD8 (a chromatin remodeler)-related ASD shows a strong male bias (~4:1), although the underlying mechanism remains unclear. Chd8-mutant mice with a C-terminal protein-truncating mutation (N2373K) display male-preponderant behavioral deficits as juveniles and adults, although whether this also applies to other Chd8 mutations remains unknown. In addition, it remains unclear whether sexually dimorphic phenotypes in Chd8-mutant mice are differentially observed in males and females across different ages. We here generated new Chd8-mutant (knock-in) mice carrying a patient-derived mutation causing an N-terminal and stronger protein truncation (Chd8^+/S62X mice) and ch

SUBMITTER: Lee SY 

PROVIDER: S-EPMC9641250 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature