Identification of diagnostic markers related to fecal and plasma metabolism in primary Sjogren's syndrome.

ABSTRACT:

Background

Accurate diagnostic techniques for patients with primary Sjögren's syndrome (pSS) are needed. This study aimed to investigate new biomarkers related to fecal and plasma metabolism from pSS patients.

Methods

The feces and plasma of 21 pSS patients and 18 controls admitted to the Second Hospital of Shanxi Medical University were collected for analysis. Metabolites in feces and plasma were quantified using liquid chromatography-mass spectrometry. The metabolic pathway alterations caused by pSS were studied and the expression of metabolites in the intersecting pathway was analyzed in the feces and plasma of pSS patients. Metabolites that showed the same alterations in feces and plasma in pSS patients were considered as diagnostic markers and receiver operating charact

SUBMITTER: Han J 

PROVIDER: S-EPMC9641496 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature