Association of depression with mortality in nationwide twins: The mediating role of dementia.

ABSTRACT:

Background

The differential impact of depression across different periods in life on mortality remains inconclusive. We aimed to examine the association of depression that occurs at different age with all-cause mortality, and to explore the roles of dementia, as well as genetic and early-life environmental factors, in this association.

Methods

From the Swedish Twin Registry, 44,919 twin individuals were followed for up to 18 years. Depression was ascertained using the National Patient Registry and categorized as early-life (<45 years), midlife (45-64 years), and late-life (≥65 years) depression according to the age of the first diagnosis. Deaths were identified through the Cause of Death Register. Generalized estimating equation, generalized structural equation, and conditio

SUBMITTER: Yang W 

PROVIDER: S-EPMC9641650 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature