Click functionalized biocompatible gadolinium oxide core-shell nanocarriers for imaging of breast cancer cells.

ABSTRACT: Site-specific delivery using functionalized nanocarriers is in high demand in imaging applications of modern clinical research. To improve the imaging capabilities of conventionally used contrast agents and expand the targeting accuracy, functional gadolinium oxide based nanocarriers originated from homogeneous core shells structures (Gd₂O₃@SiO₂@Fe₃O₄) were developed using a multilayer formation approach. The synthesis and chemical configuration for the covalent binding of macrocyclic chelating agents and estrogen targeting molecules on these nanocarriers were designed by a two-step chemical synthesis method. Initially, SiO₂@Fe₃O₄ structures were prepared and encapsulated with a homogenous thin Gd₂

SUBMITTER: Siribbal SM 

PROVIDER: S-EPMC9641724 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature