Cladribine treatment improves cortical network functionality in a mouse model of autoimmune encephalomyelitis.

ABSTRACT:

Background

Cladribine is a synthetic purine analogue that interferes with DNA synthesis and repair next to disrupting cellular proliferation in actively dividing lymphocytes. The compound is approved for the treatment of multiple sclerosis (MS). Cladribine can cross the blood-brain barrier, suggesting a potential effect on central nervous system (CNS) resident cells. Here, we explored compartment-specific immunosuppressive as well as potential direct neuroprotective effects of oral cladribine treatment in experimental autoimmune encephalomyelitis (EAE) mice.

Methods

In the current study, we compare immune cell frequencies and phenotypes in the periphery and CNS of EAE mice with distinct grey and white matter lesions (combined active and focal EAE) either orally treated with

SUBMITTER: Schroeter CB 

PROVIDER: S-EPMC9641831 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature