Corticotropin-stimulated steroid profiles to predict shock development and mortality in sepsis: From the HYPRESS study.

ABSTRACT:

Rationale

Steroid profiles in combination with a corticotropin stimulation test provide information about steroidogenesis and its functional reserves in critically ill patients.

Objectives

We investigated whether steroid profiles before and after corticotropin stimulation can predict the risk of in-hospital death in sepsis.

Methods

An exploratory data analysis of a double blind, randomized trial in sepsis (HYPRESS [HYdrocortisone for PRevention of Septic Shock]) was performed. The trial included adult patients with sepsis who were not in shock and were randomly assigned to placebo or hydrocortisone treatment. Corticotropin tests were performed in patients prior to randomization and in healthy subjects. Cortisol and precursors of glucocorticoids (17-OH-progesterone, 11

SUBMITTER: Briegel J 

PROVIDER: S-EPMC9641871 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature