CHRNB2 represses pancreatic cancer migration and invasion via inhibiting β-catenin pathway.

ABSTRACT:

Background

Pancreatic cancer is one of the most lethal disease with highly fatal and aggressive properties. Lymph node ratio (LNR), the ratio of the number of metastatic lymph nodes to the total number of examined lymph nodes, is an important index to assess lymphatic metastasis and predict prognosis, but the molecular mechanism underlying high LNR was unclear.

Methods

Gene expression and clinical information data of pancreatic cancer were obtained from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO). Patients in TCGA were averagely divided into low and high LNR groups. Then, Weighted Gene Co-expression Network Analysis (WGCNA) was utilized to build co-expression network to explore LNR-related modules and hub genes. GO and KEGG analysis was performed to find

SUBMITTER: Qin C 

PROVIDER: S-EPMC9641890 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature