Custom gene expression panel for evaluation of potential molecular markers in hepatocellular carcinoma.

ABSTRACT:

Background

Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related mortality worldwide. It is a highly heterogeneous disease with poor prognosis and limited treatment options, which highlights the need for reliable biomarkers. This study aims to explore molecular markers that allow stratification of HCC and may lead to better prognosis and treatment prediction.

Materials and methods

We studied 20 candidate genes (HCC hub genes, potential drug target genes, predominant somatic mutant genes) retrieved from literature and public databases with potential to be used as the molecular markers. We analysed expression of the genes by RT-qPCR in 30 HCC tumour and adjacent non-tumour paired samples from Vietnamese patients. Fold changes in expression were then dete

SUBMITTER: Pallerla SR 

PROVIDER: S-EPMC9641913 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature