Denisovan and Neanderthal archaic introgression differentially impacted the genetics of complex traits in modern populations.

ABSTRACT:

Background

Introgression from extinct Neanderthal and Denisovan human species has been shown to contribute to the genetic pool of modern human populations and their phenotypic spectrum. Evidence of how Neanderthal introgression shaped the genetics of human traits and diseases has been extensively studied in populations of European descent, with signatures of admixture reported for instance in genes associated with pigmentation, immunity, and metabolic traits. However, limited information is currently available about the impact of archaic introgression on other ancestry groups. Additionally, to date, no study has been conducted with respect to the impact of Denisovan introgression on the health and disease of modern populations. Here, we compare the way evolutionary pressures shaped

SUBMITTER: Koller D 

PROVIDER: S-EPMC9641937 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature