White matter microstructural integrity pre- and post-treatment in individuals with chronic post-stroke aphasia.

ABSTRACT: While previous studies have found that white matter damage relates to impairment severity in individuals with aphasia, further study is required to understand the relationship between white matter integrity and treatment response. In this study, 34 individuals with chronic post-stroke aphasia underwent behavioral testing and structural magnetic resonance imaging at two timepoints. Thirty participants within this sample completed typicality-based semantic feature treatment for anomia. Tractography of bi-hemispheric white matter tracts was completed via Automated Fiber Quantification. Associations between microstructural integrity metrics and behavioral measures were evaluated at the tract level and in nodes along the tract. Diffusion measures of the left inferior longitudinal, superior long

SUBMITTER: Braun EJ 

PROVIDER: S-EPMC9641951 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature