Severe abacavir hypersensitivity reaction in a patient with human immunodeficiency virus infection: a case report.

ABSTRACT:

Background

Abacavir is a nucleoside reverse transcriptase inhibitor that is used as a component of the antiretroviral treatment regimen in the management of the human immunodeficiency virus for both adults and children. It is efficacious, but its use may be limited by a hypersensitivity reaction linked with the HLA-B*57:01 genotype. HLA-B*57:01 has been reported to be rare in African populations. Because of the nature of its presentation, abacavir hypersensitivity is prone to late diagnosis and treatment, especially in settings where HLA-B*57:01 genotyping is not routinely done.

Case report

We report a case of a severe hypersensitivity reaction in a 44-year-old Kenyan female living with the human immunodeficiency virus and on abacavir-containing antiretroviral therapy. The p

SUBMITTER: Koech MK 

PROVIDER: S-EPMC9641955 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature