Magnetique: an interactive web application to explore transcriptome signatures of heart failure.

ABSTRACT:

Background

Despite a recent increase in the number of RNA-seq datasets investigating heart failure (HF), accessibility and usability remain critical issues for medical researchers. We address the need for an intuitive and interactive web application to explore the transcriptional signatures of heart failure with this work.

Methods

We reanalysed the Myocardial Applied Genomics Network RNA-seq dataset, one of the largest publicly available datasets of left ventricular RNA-seq samples from patients with dilated (DCM) or hypertrophic (HCM) cardiomyopathy, as well as unmatched non-failing hearts (NFD) from organ donors and patient characteristics that allowed us to model confounding factors. We analyse differential gene expression, associated pathway signatures and reconstruct si

SUBMITTER: Britto-Borges T 

PROVIDER: S-EPMC9641957 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature