GM-CSF⁺ Tc17 cells are required to bolster vaccine immunity against lethal fungal pneumonia without causing overt pathology.

ABSTRACT: GM-CSF co-expressing T17 cells instigate pathologic inflammation during autoimmune disorders, but their function in immunity to infections is unclear. Here, we demonstrate the role of GM-CSF⁺Tc17 cells for vaccine immunity against lethal fungal pneumonia and the cytokine requirements for their induction and memory homeostasis. Vaccine-induced GM-CSF⁺ Tc17 cells are necessary to bolster pulmonary fungal immunity without inflating pathology. Although GM-CSF expressing Tc17 cells preferentially elevate during the memory phase, their phenotypic attributes strongly suggest they are more like Tc17 cells than IFNγ-producing Tc1 cells. IL-1 and IL-23, but not GM-CSF, are necessary to elicit GM-CSF⁺ Tc17 cells following vaccination. IL-23 is dispensable for memory T

SUBMITTER: Mudalagiriyappa S 

PROVIDER: S-EPMC9641983 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature