Lesions causing post-stroke spasticity localize to a common brain network.

ABSTRACT:

Objective

The efficacy of clinical interventions for post-stroke spasticity (PSS) has been consistently unsatisfactory, probably because lesions causing PSS may occur at different locations in the brain, leaving the neuroanatomical substrates of spasticity unclear. Here, we investigated whether heterogeneous lesions causing PSS were localized to a common brain network and then identified the key nodes in this network.

Methods

We used 32 cases of PSS and the Human Connectome dataset (n = 1,000), using a lesion network mapping method to identify the brain regions that were associated with each lesion in patients with PSS. Functional connectivity maps of all lesions were overlaid to identify common connectivity. Furthermore, a split-half replication method was used to ev

SUBMITTER: Qin Y 

PROVIDER: S-EPMC9642815 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature