Cerebrospinal fluid and arterial acid-base equilibria in spontaneously breathing third-trimester pregnant women.

ABSTRACT:

Background

Acid-base status in full-term pregnant women is characterised by hypocapnic alkalosis. Whether this respiratory alkalosis is primary or consequent to changes in CSF electrolytes is not clear.

Methods

We enrolled third-trimester pregnant women (pregnant group) and healthy, non-pregnant women of childbearing age (controls) undergoing spinal anaesthesia for Caesarean delivery and elective surgery, respectively. Electrolytes, strong ion difference (SID), partial pressure of carbon dioxide ( [Formula: see text] ), and pH were measured in simultaneously collected CSF and arterial blood samples.

Results

All pregnant women (20) were hypocapnic, whilst only four (30%) of the controls (13) had an arterial [Formula: see text] <4.7 kPa (P<0.001). The incidence of hypoc

SUBMITTER: Zadek F 

PROVIDER: S-EPMC9642833 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature