HIV skews the SARS-CoV-2 B cell response towards an extrafollicular maturation pathway.

ABSTRACT:

Background

HIV infection dysregulates the B cell compartment, affecting memory B cell formation and the antibody response to infection and vaccination. Understanding the B cell response to SARS-CoV-2 in people living with HIV (PLWH) may explain the increased morbidity, reduced vaccine efficacy, reduced clearance, and intra-host evolution of SARS-CoV-2 observed in some HIV-1 coinfections.

Methods

We compared B cell responses to COVID-19 in PLWH and HIV negative (HIV-ve) patients in a cohort recruited in Durban, South Africa, during the first pandemic wave in July 2020 using detailed flow cytometry phenotyping of longitudinal samples with markers of B cell maturation, homing, and regulatory features.

Results

This revealed a coordinated B cell response to COVID-19 that d

SUBMITTER: Krause R 

PROVIDER: S-EPMC9643005 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature