A diffusion tensor imaging analysis of white matter microstructures in non-operated craniosynostosis patients.

ABSTRACT:

Purpose

In 7 to 15-year-old operated syndromic craniosynostosis patients, we have shown the presence of microstructural anomalies in brain white matter by using DTI. To learn more about the cause of these anomalies, the aim of the study is to determine diffusivity values in white matter tracts in non-operated syndromic craniosynostosis patients aged 0-2 years compared to healthy controls.

Methods

DTI datasets of 51 non-operated patients with syndromic craniosynostosis with a median [IQR] age of 0.40 [0.25] years were compared with 17 control subjects with a median of 1.20 [0.85] years. Major white matter tract pathways were reconstructed with ExploreDTI from MRI brain datasets acquired on a 1.5 T MRI system. Eigenvalues of these tract data were examined, with subsequent asse

SUBMITTER: de Planque CA 

PROVIDER: S-EPMC9643264 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature