Regulated cell death: Implications for intervertebral disc degeneration and therapy.

ABSTRACT: As a controllable biological process, regulated cell death (RCD) extensively participates in cellular homeostasis, organismal development, and the pathogenesis of diseases. This review addresses the research gaps by synthesising the findings on the complexity of RCD modes and their role in disc degeneration, and summarises the preclinical strategies to alleviate disc degeneration and promote disc repair by regulating RCD.

Background

Intervertebral disc degeneration (IDD) is the major source of chronic low back pain. As a controllable biological process, regulated cell death (RCD) extensively participates in the pathogenesis of IDD. Nevertheless, the initiation and progression of RCD remain unclear, and more importantly, the interaction between different RCD modes during IDD and ther

SUBMITTER: Yang F 

PROVIDER: S-EPMC9643304 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature