Maternal diabetes and childhood cancer risks in offspring: two population-based studies.

ABSTRACT:

Background

The effect of maternal diabetes on childhood cancer has not been widely studied.

Methods

We examined this in two population-based studies in Denmark (N = 6420 cancer cases, 160,484 controls) and Taiwan (N = 2160 cancer cases, 2,076,877 non-cases) using logistic regression and Cox proportional hazard regression adjusted for birth year, child's sex, maternal age and birth order.

Results

Gestational diabetes in Denmark [odds ratio (OR) = 0.98, 95% confidence interval (CI): 0.71-1.35] or type II and gestational diabetes in Taiwan (type II: hazard ratio (HR) = 0.81, 95% CI: 0.63-1.05; gestational diabetes: HR = 1.06, 95% CI: 0.92-1.22) were not associated with cancer (all types combined). In Denmark, maternal type I diabetes was associated with the risk of gliom

SUBMITTER: Huang X 

PROVIDER: S-EPMC9643384 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature