Ocular morphologic traits in the American Cocker Spaniel may confer primary angle closure glaucoma susceptibility.

ABSTRACT: Acute primary angle closure glaucoma is a potentially blinding ophthalmic emergency requiring prompt treatment to lower the elevated intraocular pressure in humans and dogs. The PACG in most of canine breeds is epidemiologically similar to humans with older and female patients overrepresented with the condition. The American Cocker Spaniel (ACS) is among the most common breeds observed with PACG development in dogs. This study initially sought to identify genetic risk factors to explain the high prevalence of PACG in ACSs by using a case-control breed-matched genome-wide association study. However, the GWAS failed to identify candidate loci associated with PACG in this breed. This study then assessed intrinsic ocular morphologic traits that may relate to PACG susceptibility in this breed.

SUBMITTER: Park S 

PROVIDER: S-EPMC9643544 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature