Three-dimensional mapping reveals heterochronic development of the neuromuscular system in postnatal mouse skeletal muscles.

ABSTRACT: The development of the neuromuscular system, including muscle growth and intramuscular neural development, in addition to central nervous system maturation, determines motor ability improvement. Motor development occurs asynchronously from cephalic to caudal. However, whether the structural development of different muscles is heterochronic is unclear. Here, based on the characteristics of motor behavior in postnatal mice, we examined the 3D structural features of the neuromuscular system in different muscles by combining tissue clearing with optical imaging techniques. Quantitative analyses of the structural data and related mRNA expression revealed that there was continued myofiber hyperplasia of the forelimb and hindlimb muscles until around postnatal day 3 (P3) and P6, respectively, as

SUBMITTER: Xu J 

PROVIDER: S-EPMC9643545 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature