Gender-related differentially expressed genes in pancreatic cancer: possible culprits or accomplices?

ABSTRACT: Pancreatic cancer (PC) is one of the leading causes of cancer mortality worldwide, and its incidence and mortality rate in several regions is higher in male patients. Although numerous efforts have been made to enhance the clinical outcomes of existing therapeutic regimens, their efficiency is still low, and drug resistance usually occurs in many patients. In addition, the exact underlying molecular basis that makes PC slightly more prevalent among males remains unknown. Providing information regarding the possible association between gender and PC tumorigenesis may offer important clues for how certain molecular cross-talks can affect PC initiation and/or progression. In this study, we used several microarray expression data to identify the common up- and downregulated genes within one sp

SUBMITTER: Ramezankhani R 

PROVIDER: S-EPMC9643577 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature