ATM/ATR kinases link the synaptonemal complex and DNA double-strand break repair pathway choice.

ABSTRACT: DNA double-strand breaks (DSBs) are deleterious lesions, which must be repaired precisely to maintain genomic stability. During meiosis, programmed DSBs are repaired via homologous recombination (HR) while repair using the nonhomologous end joining (NHEJ) pathway is inhibited, thereby ensuring crossover formation and accurate chromosome segregation.^1,2 How DSB repair pathway choice is implemented during meiosis is unknown. In C. elegans, meiotic DSB repair takes place in the context of the fully formed, highly dynamic zipper-like structure present between homologous chromosomes called the synaptonemal complex (SC).^3,4,5,6,7,8,<

SUBMITTER: Lascarez-Lagunas LI 

PROVIDER: S-EPMC9643613 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature