Multiancestral polygenic risk score for pediatric asthma.

ABSTRACT:

Background

Asthma is the most common chronic condition in children and the third leading cause of hospitalization in pediatrics. The genome-wide association study catalog reports 140 studies with genome-wide significance. A polygenic risk score (PRS) with predictive value across ancestries has not been evaluated for this important trait.

Objectives

This study aimed to train and validate a PRS relying on genetic determinants for asthma to provide predictions for disease occurrence in pediatric cohorts of diverse ancestries.

Methods

This study applied a Bayesian regression framework method using the Trans-National Asthma Genetic Consortium genome-wide association study summary statistics to derive a multiancestral PRS score, used one Electronic Medical Records and Genom

SUBMITTER: Namjou B 

PROVIDER: S-EPMC9643615 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature