Excessive IL-10 and IL-18 trigger hemophagocytic lymphohistiocytosis-like hyperinflammation and enhanced myelopoiesis.

ABSTRACT:

Background

Hyperinflammation is a life-threatening condition associated with various clinical disorders characterized by excessive immune activation and tissue damage. Multiple cytokines promote the development of hyperinflammation; however, the contribution of IL-10 remains unclear despite emerging speculations for a pathological role. Clinical observations from hemophagocytic lymphohistiocytosis (HLH), a prototypical hyperinflammatory disease, suggest that IL-18 and IL-10 may collectively promote the onset of a hyperinflammatory state.

Objective

We aimed to investigate the collaborative roles of IL-10 and IL-18 in hyperinflammation.

Methods

A comprehensive plasma cytokine profile for 87 secondary HLH patients was first depicted and analyzed. We then investigated the

SUBMITTER: Tang Y 

PROVIDER: S-EPMC9643619 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature