Consensus and guidelines on lipoprotein(a) - seeing the forest through the trees.

ABSTRACT:

Purpose of the review

Over the past decade, lipoprotein(a) [Lp(a)] made it to several consensus and guideline documents. This review aims to summarize the literature which underlies the various recommendations and compares recent European and North American consensus and guideline documents of the recent 3-4 years.

Recent findings

Multiple large epidemiological and genetic studies have provided strong evidence for a causal association between Lp(a) concentrations and atherosclerotic cardiovascular disease (ASCVD) and aortic valve stenosis. There is a dose-dependent linear relationship between Lp(a) and ASCVD risk advocating to consider Lp(a) on a continuous scale rather than using thresholds. The best way to implement this in the clinic is by individualizing the Lp(a)-relate

SUBMITTER: Kronenberg F 

PROVIDER: S-EPMC9643632 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature