Orbitofrontal cortex populations are differentially recruited to support actions.

ABSTRACT: The ability to use information from one's prior actions is necessary for decision-making. While orbitofrontal cortex (OFC) has been hypothesized as key for inferences made using cue and value-related information, whether OFC populations contribute to the use of information from volitional actions to guide behavior is not clear. Here, we used a self-paced lever-press hold-down task in which mice infer prior lever-press durations to guide subsequent action performance. We show that the activity of genetically identified lateral OFC (lOFC) subpopulations differentially instantiate current and prior action information during ongoing action execution. Transient state-dependent lOFC circuit disruptions of specified subpopulations reduced the encoding of ongoing press durations but did not disrup

SUBMITTER: Cazares C 

PROVIDER: S-EPMC9643660 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature