Copy number variants and placental abnormalities in stillborn fetuses: A secondary analysis of the Stillbirth Collaborative Research Network study.

ABSTRACT:

Objective

To examine the association of fetal/placental DNA copy number variants (CNVs) with pathologic placental lesions (PPLs) in pregnancies complicated by stillbirth.

Design

A secondary analysis of stillbirth cases in the Stillbirth Collaborative Research Network case-control study.

Setting

Multicenter, 59 hospitals in five geographical regions in the USA.

Population

387 stillbirth cases (2006-2008).

Methods

Using standard definitions, PPLs were categorised by type including maternal vascular, fetal vascular, inflammatory and immune/idiopathic lesions. Single-nucleotide polymorphism array detected CNVs of at least 500 kb. CNVs were classified into two groups: normal, defined as no CNV >500 kb or benign CNVs, and abnormal, defined as pathogenic or var

SUBMITTER: Workalemahu T 

PROVIDER: S-EPMC9643668 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature