Relationship between the subgingival microbiome and menopausal hormone therapy use: The Buffalo OsteoPerio study.

ABSTRACT:

Background

This study investigated the association between menopausal hormone therapy (HT) use and the subgingival microbiome, for which published information is limited.

Methods

This cross-sectional study included 1270 postmenopausal women, aged 53-81 years, who completed clinical examinations. Detailed information on HT use (type, delivery mode, duration) was obtained from questionnaires. HT use was categorized into three groups (never, former, current). 16S rRNA sequencing was performed on subgingival plaque samples obtained during dental examinations. Operational taxonomic units were centered log2-ratio (CLR) transformed to account for the compositional data structure. Analysis of variance was used to compare mean microbial relative abundances across HT categories with B

SUBMITTER: Soliman AI 

PROVIDER: S-EPMC9643674 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature