Association between quetiapine use and self-harm outcomes among people with recorded personality disorder in UK primary care: A self-controlled case series analysis.

ABSTRACT:

Background

Quetiapine is frequently prescribed to people with personality disorder diagnoses, but this is not supported by evidence or treatment guidelines.

Aims

To examine associations between periods of quetiapine prescribing and self-harm events in people with personality disorder.

Method

Self-controlled case series using linked primary care and hospital records covering the period 2007-2017. We calculated incidence rates and incidence rate ratios (IRRs) for self-harm events during periods when people were prescribed (exposed to) quetiapine, as well as periods when they were unexposed or pre-exposed to quetiapine.

Results

We analysed data from 1,082 individuals with established personality disorder diagnoses, all of whom had at least one period of quetiapine

SUBMITTER: Hayes JF 

PROVIDER: S-EPMC9643813 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature