Polyphenols: Chemoprevention and therapeutic potentials in hematological malignancies.

ABSTRACT: Polyphenols are one of the largest plant-derived natural product and they play an important role in plants' defense as well as in human health and disease. A number of them are pleiotropic molecules and have been shown to regulate signaling pathways, immune response and cell growth and proliferation which all play a role in cancer development. Hematological malignancies on the other hand, are cancers of the blood. While current therapies are efficacious, they are usually expensive and with unwanted side effects. Thus, the search for newer less toxic agents. Polyphenols have been reported to possess antineoplastic properties which include cell cycle arrest, and apoptosis via multiple mechanisms. They also have immunomodulatory activities where they enhance T cell activation and suppress reg

SUBMITTER: Izuegbuna OO 

PROVIDER: S-EPMC9643866 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature