CD3e-immunotoxin spares CD62L^lo Tregs and reshapes organ-specific T-cell composition by preferentially depleting CD3e^hi T cells.

ABSTRACT: CD3-epsilon(CD3e) immunotoxins (IT), a promising precision reagent for various clinical conditions requiring effective depletion of T cells, often shows limited treatment efficacy for largely unknown reasons. Tissue-resident T cells that persist in peripheral tissues have been shown to play pivotal roles in local and systemic immunity, as well as transplant rejection, autoimmunity and cancers. The impact of CD3e-IT treatment on these local cells, however, remains poorly understood. Here, using a new murine testing model, we demonstrate a substantial enrichment of tissue-resident Foxp3+ Tregs following CD3e-IT treatment. Differential surface expression of CD3e among T-cell subsets appears to be a main driver of Treg enrichment in CD3e-IT treatment. The surviving Tregs in CD3e-IT-treated mic

SUBMITTER: Kim S 

PROVIDER: S-EPMC9643874 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature