Grape polyphenols decrease circulating branched chain amino acids in overfed adults.

ABSTRACT:

Introduction and aims

Dietary polyphenols have long been associated with health benefits, including the prevention of obesity and related chronic diseases. Overfeeding was shown to rapidly induce weight gain and fat mass, associated with mild insulin resistance in humans, and thus represents a suitable model of the metabolic complications resulting from obesity. We studied the effects of a polyphenol-rich grape extract supplementation on the plasma metabolome during an overfeeding intervention in adults, in two randomized parallel controlled clinical trials.

Methods

Blood plasma samples from 40 normal weight to overweight male adults, submitted to a 31-day overfeeding (additional 50% of energy requirement by a high calorie-high fructose diet), given either 2 g/day grape poly

SUBMITTER: Bartova S 

PROVIDER: S-EPMC9643885 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature