Association of sleep abnormalities in older adults with risk of developing Parkinson's disease.

ABSTRACT:

Study objectives

Parkinson's disease (PD) is associated with abnormalities of sleep macro- and microstructure as measured using polysomnography (PSG). Whether these abnormalities precede the development of PD is unknown. This study investigated the association between PSG measured sleep abnormalities in older adults and the risk of incident PD.

Methods

A total of 2,770 men from the ancillary sleep study of the Osteoporotic Fractures in Men Study (MrOS), a population-based cohort from the United States, who were free from PD baseline and underwent overnight PSG, were included in this longitudinal analysis. Incident PD was based on a clinical diagnosis from a medical professional. Multivariable logistic regression was used to estimate odds ratios (OR) for incident PD by quarti

SUBMITTER: Otaiku AI 

PROVIDER: S-EPMC9644115 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature