Preferences of patients for benefits and risks of insomnia medications using data elicited during two phase III clinical trials.

ABSTRACT:

Study objectives

To elicit the trade-offs patients are willing to make between benefits and risks of medications for chronic insomnia, with the purpose of allowing a patient-centric interpretation of clinical trial data.

Methods

A discrete choice experiment (DCE) was included in the two placebo-controlled phase III trials that evaluated the efficacy and safety of daridorexant. The DCE design was informed by a two-phase qualitative study, followed by qualitative and quantitative pilot testing before fielding. Relative attribute importance (RAI) and acceptable trade-offs between benefits and risks were obtained using a mixed logit model.

Results

Preferences were elicited from 602 trial participants (68.1% female, aged 58.6 ± 14.5 years). Preferences were most affected b

SUBMITTER: Heidenreich S 

PROVIDER: S-EPMC9644122 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature