Frontal grey matter microstructure is associated with sleep slow waves characteristics in late midlife.

ABSTRACT:

Study objectives

The ability to generate slow waves (SW) during non-rapid eye movement (NREM) sleep decreases as early as the 5th decade of life, predominantly over frontal regions. This decrease may concern prominently SW characterized by a fast switch from hyperpolarized to depolarized, or down-to-up, state. Yet, the relationship between these fast and slow switcher SW and cerebral microstructure in ageing is not established.

Methods

We recorded habitual sleep under EEG in 99 healthy late midlife individuals (mean age = 59.3 ± 5.3 years; 68 women) and extracted SW parameters (density, amplitude, frequency) for all SW as well as according to their switcher type (slow vs. fast). We further used neurite orientation dispersion and density imaging (NODDI) to assess microstructu

SUBMITTER: Chylinski D 

PROVIDER: S-EPMC9644125 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature