Association of enlarged perivascular spaces with upper extremities and gait impairment: An observational, prospective cohort study.

ABSTRACT:

Background and objective

Gait disturbances are common in the elderly and can lead to the loss of functional independence and even death. Enlarged perivascular space (EPVS) and motor performance may be related, but only few studies have explored this relationship. The aim of our study was to investigate the effects of both the severity and location of EPVS on movement disorders.

Method

Two hundred and six participants aged between 45 and 85 years old with complete magnetic resonance imaging (MRI) data were included in our analysis. EPVS were divided into basal ganglia (BG) and centrum semiovale (CSO), and their grades were measured. Gait was assessed quantitatively using a 4-m walkway and TUG test as well as semi-quantitatively using the Tinetti and SPPB tests. The function o

SUBMITTER: Hou Y 

PROVIDER: S-EPMC9644133 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature