Identification of a novel role for matrix metalloproteinase-3 in the modulation of B cell responses in multiple sclerosis.

ABSTRACT: There has been a growing interest in the presence and role of B cell aggregates within the central nervous system of multiple sclerosis patients. However, very little is known about the expression profile of molecules associated with these aggregates and how they might be influencing aggregate development or persistence in the brain. The current study focuses on the effect of matrix metalloproteinase-3, which is associated with B cell aggregates in autopsied multiple sclerosis brain tissue, on B cells. Autopsied brain sections from multiple sclerosis cases and controls were screened for the presence of CD20⁺ B cell aggregates and expression of matrix metalloproteinase-3. Using flow cytometry, enzyme-linked immunosorbent assay and gene array as methods, in vitro studies we

SUBMITTER: Chunder R 

PROVIDER: S-EPMC9644161 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature