Causal relationship among obesity and body fat distribution and epilepsy subtypes.

ABSTRACT:

Objective

The observational studies indicate an association between obesity and epilepsy, but it is unclear whether such an association responds to causality. The objective of this study was to determine the causal relationship between obesity and fat distribution and epilepsy subtypes based on waist circumference, hip circumference (HP), waist-hip ratio (WHR), and body mass index (BMI).

Methods

A two-sample Mendelian randomization study was conducted separately for the four indicators of obesity and epilepsy and its seven subtypes, with reverse Mendelian randomization and multivariate Mendelian randomization for significant outcomes.

Results

A two-sample Mendelian randomized analysis informed us that waist circumference was a risk factor for juvenile myoclonic epilep

SUBMITTER: Zhou K 

PROVIDER: S-EPMC9644162 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature