METTL3/m⁶A/IFIT2 regulates proliferation, invasion and immunity in esophageal squamous cell carcinoma.

ABSTRACT: Epigenetic regulation plays a critical role in the development, progression, and treatment of tumors. The most common chemical modification of mRNA, called m⁶A, is essential for controlling mRNA stability, splicing, and translation. Methyltransferase-like 3 (METTL3) is an important m6A methyltransferase. The mechanism of action of METTL3 in esophageal squamous cell carcinoma (ESCC) remains unclear. In this investigation, we sought to clarify the function and clinical importance of METTL3 in ESCC and investigate its underlying mechanisms. We discovered that METTL3 has a significant proliferative effect in ESCC cells by using lentiviral construction of stable cell lines overexpressing METTL3 (METTL3-OE) and knocking down METTL3 (sh-METTL3). To create a xenograft tumor model, we in

SUBMITTER: Ge F 

PROVIDER: S-EPMC9644211 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature