Association Between Subclinical Thyroid Dysfunction and Fracture Risk.

ABSTRACT:

Importance

Clinical hyperthyroidism accelerates bone resorption without compensatory bone formation, reducing bone density and increasing the risk of fracture. The association between subclinical hyperthyroidism and fracture risk is less clear.

Objective

To investigate the association of endogenous subclinical thyroid dysfunction and fracture risk, independent of clinical confounders.

Design, setting, and participants

This cohort study included 10 946 participants from the Atherosclerosis Risk in Communities Study, an ongoing prospective cohort study of community-dwelling individuals conducted from 1987-1989 through December 31, 2019, in Washington County, Maryland; Forsyth County, North Carolina; Jackson, Mississippi; and the suburbs of Minneapolis, Minnesota. Partic

SUBMITTER: Daya NR 

PROVIDER: S-EPMC9644261 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature