Prospective cohort study of prevention of mother to child transmission of hepatitis B infection and 9 months follow-up of hepatitis B-exposed infants at Ile-Ife, Nigeria.

ABSTRACT:

Objectives

Eliminating mother-to-child transmission (MTCT) of hepatitis B virus (HBV) is central to WHO's target of reducing hepatitis B infection in children to <0.1% by 2030. While Nigeria accounts for 8.3% of the global burden, interventional studies on prevention of MTCT of HBV are hardly available. This study aimed to assess the impact of prevention of MTCT interventions on vertical transmission of HBV among pregnant women in Nigeria.

Design

A prospective cohort study.

Setting

A University Teaching Hospitals Complex in Nigeria between 2015 and 2021.

Participants

10 866 pregnant women and their pre-existing children.

Interventions

Eligible pregnant women were screened for HBsAg using chromatographic immunoassay (Micropoint, USA). HbsAg-positive women

SUBMITTER: Ndububa D 

PROVIDER: S-EPMC9644333 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature