Raman Spectroscopic Tools to Probe the Skin-(Trans)dermal Formulation Interface.

ABSTRACT: Medicines designed to deliver the active pharmaceutical ingredient either into or through the skin─often referred to as topicals and transdermals, respectively─are generally considered to be complex drug products. A particular challenge faced by these formulations is identifying a suitable method (ideally, in terms of specificity, accuracy, precision, and robustness) or combination of methods with which to assess the amount and rate of drug delivery to the target site. Significant research currently aims to identify and validate relevant and minimally invasive techniques that can be used to quantify both the levels of the drug attained within different parts of the skin and the kinetics with which the drug is taken up into the skin and cleared therefrom into the systemic circulation. Here,

SUBMITTER: Garvie-Cook H 

PROVIDER: S-EPMC9644382 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature