Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey.

ABSTRACT: Despite increasing evidence that uveitis is common and consequential in survivors of Ebola virus disease (EVD), the host-pathogen determinants of the clinical phenotype are undefined, including the pathogenetic role of persistent viral antigen, ocular tissue-specific immune responses, and histopathologic characterization. Absent sampling of human intraocular fluids and tissues, these questions might be investigated in animal models of disease; however, challenges intrinsic to the nonhuman primate model and the animal biosafety level 4 setting have historically limited inquiry. In a rhesus monkey survivor of experimental Ebola virus (EBOV) infection, we observed and documented the clinical, virologic, immunologic, and histopathologic features of severe uveitis. Here we show the clinical nat

SUBMITTER: Worwa G 

PROVIDER: S-EPMC9644391 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature