Ontology highlight
ABSTRACT:
SUBMITTER: Musa M
PROVIDER: S-EPMC9644420 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Musa Marina M Dionisio Pedro A PA Casqueiro Ricardo R Milosevic Ira I Raimundo Nuno N Krisko Anita A
Life science alliance 20221108 1
Exact mechanisms of heat shock-induced lifespan extension, although documented across species, are still not well understood. Here, we show that fully functional peroxisomes, specifically peroxisomal catalase, are needed for the activation of canonical heat shock response and heat-induced hormesis in <i>Caenorhabditis elegans</i> Although during heat shock, the HSP-70 chaperone is strongly up-regulated in the WT and in the absence of peroxisomal catalase (<i>ctl-2(ua90)II</i>), the small heat sh ...[more]