Body mass index and incidence of lung cancer in the HUNT study: using observational and Mendelian randomization approaches.

ABSTRACT:

Background

Traditional observational studies have shown an inverse association between body mass index (BMI) and lung cancer risk. Mendelian randomization (MR) analysis using genetic variants as instruments for BMI may clarify the nature of the association.

Aims

We studied the causal association between BMI and lung cancer incidence using observational and MR approaches.

Methods

We followed up 62,453 cancer-free Norwegian adults from 1995-97 (HUNT2) until 2017. BMI at baseline in HUNT2 was classified as < 25.0, 25.0-29.9 and ≥ 30.0 kg/m². BMI change over ten years between HUNT1 (1984-86) and HUNT2 was calculated and classified into quartiles. Seventy-five genetic variants were included as instruments for BMI (among which 14 also associated with smoking beha

SUBMITTER: Jiang L 

PROVIDER: S-EPMC9644519 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature