Inhibition of AEBP1 predisposes cisplatin-resistant oral cancer cells to ferroptosis.

ABSTRACT:

Background

Studies have shown that excessive iron can lead to an increased incidence of cancer. The role of adipocyte enhancer-binding protein 1 (AEBP1) on ferroptosis is unknown. Thus, we explored the effect of AEBP1 silencing in regulation of ferroptosis in cisplatin-resistant oral cancer cells.

Methods

The functions of AEBP1 silencing and sulfasalazine (SSZ) treatment were determined on oral cancer cell lines and tumor xenograft mouse models. Then we evaluated the functions of AEBP1 on cell proliferation, migration, invasion, lipid reactive oxygen species (ROS), labile iron pool (LIP) and free iron, lipid peroxidation, and expression levels of ferroptosis-related genes.

Results

AEBP1 was highly expressed in oral cancer cells and tissues. AEBP1 silencing inhibited o

SUBMITTER: Zhou Q 

PROVIDER: S-EPMC9644533 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature